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in quarto
in quarto 是固定短语，常与 publish、print、issue 等动词搭配，表示“以四开本形式”。
The play was first published in quarto in 1594.
该剧于1594年首次以四开本形式出版。
四开；四开本
先理解核心含义，再看它在真实句子里的用法。
四开；四开本
a book size made by folding a sheet of paper twice to form four leaves
The play was first published in quarto in 1594.
该剧于1594年首次以四开本形式出版。
A size of paper (7.5"-10" x 10"-12.5" or 190-254 x 254-312 mm). Formed by folding and cutting one of several standard sizes of paper (15"-20" x 20"-25" or 381-508 x 508-635 mm) twice to form 4 leaves (eight sides).
A book size, corresponding to the paper size.
The auction house sold a first-edition quarto for over ten thousand dollars.
拍卖行以一万多美元售出一本初版四开本。
In the sixteenth century, printers often produced a quarto to save paper and reduce costs.
在十六世纪，印刷商常制作四开本以节省纸张和降低成本。
I found the poem in an old quarto that had been forgotten on the top shelf.
我在一本被遗忘在顶层书架上的旧四开本里找到了这首诗。
in quarto 是固定短语，常与 publish、print、issue 等动词搭配，表示“以四开本形式”。
The play was first published in quarto in 1594.
该剧于1594年首次以四开本形式出版。
quarto 是可数名词，复数形式为 quartos；修饰语可放在其前描述版本特征。
A rare quarto was displayed in the exhibition.
一本珍贵的四开本在展览中展出。
Not this
This book is quarto.
Use this
This book is a quarto.
汉语“四开”可以作定语，但英语 quarto 是可数名词，意为“四开本的书”。在表语位置指称书的类型时，需要加不定冠词 a，不能说 This book is quarto。
Not this
These are old quartoes from the library.
Use this
These are old quartos from the library.
quarto 的复数形式是直接在词尾加 -s，而不是 -es。以 -o 结尾的名词并非都加 -es，quarto 属于规则可数名词，所以应为 quartos。
Focus on the distinctions below. Other candidates are kept compact until a reliable usage note is available.
以四开本形式
In the 16th century, most plays were published in quarto.
十六世纪时，大多数戏剧都以四开本形式出版。
四开版
The museum owns a rare quarto edition of the play.
博物馆藏有一本稀有的四开版戏剧剧本。
四开本卷册
The encyclopedia was originally issued in twelve quarto volumes.
这部百科全书最初发行时共有十二卷，均为四开本。
皇家四开本
This artist's book is printed in royal quarto, with generous margins.
这本艺术家书以皇家四开本印制，页边留白宽大。
初版四开本
Scholars have dated the first quarto of this play to 1597.
学者们将这部戏剧的初版四开本年代定为1597年。
Use quarto naturally, then get feedback on meaning, tone, grammar, and phrasing.
Revisit a common error or keep this word in your review list.
记 quarto：quar 像 quarter（四分之一），书页由一张纸对折两次成四叶，所以是“四开本”。
语域：formal 常见场景：出版与印刷、古籍版本记录、藏书描述 这个词多用于出版史、古籍版本和藏书描述等专业场合，语气比较正式；日常对话中很少使用。
The words with 'quart' are lookalikes: they begin with /kwɔː/ (or /kwɒː/), like the start of 'quarto', but the final consonants differ, so they do not rhyme. The words auto, photo, and motto all contain the final /təʊ/ syllable present in 'quarto', but their stressed vowels differ (/ɔː/, /əʊ/, /ɒ/), so they are not exact rhymes either. Use them only to compare the '-to' spelling and the /təʊ/ ending.
Dictionary facts from ECDICT, WIKTIONARY.